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KMID : 0390220140250010037
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2014 Volume.25 No. 1 p.37 ~ p.43
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Association between Helicobacter Pylori Infection and Laryngopharyngeal Squamous Cell Carcinoma in Korean Population
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Cho Jae-Hyun
Han Sang-Yoon
Jang Ho-Joon
Koo Min-Bon
Ahn Dong-Bin
Yeo Chang-Ki
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Abstract
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Background and Objectives： Several studies have implicated Helicobacter pylori as a risk factor in laryngopahryngeal cancer, but other studies disagree. We investigate the possibility that H. pylori as a cause of squamous cell carcinoma of pharynx and larynx in Korean population.
Subjects and Methods： A total of 30 patients with laryngopharyngeal cancer and 41 control subjects with benign layngeal disease. Campylobacter-Like Organism (CLO) test and Cresyl-Violet stain was performed on 71 patients to identify H. pylori infection. Tissue samples were collected from tumoral tissue and benign laryngeal diseases and mucosa at posterior arytenoid area adjacent to esophagus.
Results： H. pylori was detected in 5 (16.7%) of the 30 patients with laryngopharyngeal cancer, 5 (12.2%) of the 41 patients with benign laryngeal diseases (p=0.733). The correlation between H. pylori infection and laryngopharyngeal cancer was no significant difference [OR=2.73, 95% CI (0.30-24.99)].
Conclusions：Our study shows H. pylori infection of laryngopharyngeal mucosa is not related to the possible etiologic association squamous cell carcinoma of larynx and pharynx in Korean population.
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KEYWORD
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Helicobacter pylori, Laryngeal cnacer, Pharyngeal cancer
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